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Immune Epitope Database & Analysis Resource analysis resource mhc class i mhc i prediction tools
NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
Analysis Resource Mhc Class I Mhc I Prediction Tools, supplied by Immune Epitope Database & Analysis Resource, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/analysis+resource/cell+class+ii+prediction+t+tools/pmc13044529-123-15-11
Average 86 stars, based on 1 article reviews
analysis resource mhc class i mhc i prediction tools - by Bioz Stars, 2026-10
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1) Product Images from "NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndrome"

Article Title: NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndrome

Journal: Molecular Cancer Therapeutics

doi: 10.1158/1535-7163.MCT-25-0864

NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of MHC-I–predicted binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
Figure Legend Snippet: NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of MHC-I–predicted binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.

Techniques Used:

Related Articles

other:

Article Title: SARS-CoV-2 multi-epitope subunit vaccine proof-of-concept derived from the insilico study with protein expression in Escherichia coli BL21
Article Snippet: [9] There are RANKPEP, NHL aired, SVRMHC, SYFPEITHI, and NetCTL, and recently, the most frequently used is The Immune Epitope Database and Analysis Resource (IEDB), whose database is drawn from peer-reviewed scientific literature and data submitted by previous studies.

Article Title: Genetic Complexity in Spondyloarthritis: Contributions of HLA-B Alleles Beyond HLA-B*27 in Romanian Patients
Article Snippet: The IC 50 values for assessing the binding affinity between HLA-B alleles and various peptides were computed using the Immune Epitope Database (IEDB) Analysis Resource ( http://tools.iedb.org/ , accessed on 1 July 2025).

Sequencing:

Article Title: Revolutionizing leishmaniasis control: leveraging immunoinformatics for precision-driven in-silico vaccine design.
Article Snippet: .. Identifying B-cell epitopes is crucial because of their role in antibody production, which is essential for humoral immunity.10,15 The selected sequence was analyzed using the Immune Epitope Database and Analysis Resource (IEDB)v2.28 (https://www.iedb.org/) to predict the linear B-cell epitopes of the conserved domains. ..

Article Title: Immuno-Informatics for the Rational Design of Multi-Epitope Vaccine Against Leishmania donovani.
Article Snippet: Trypanothione reductase (TryR) is a unique and key redox protein of Leishmania donovani, the causative agent of visceral Leishmaniasis.. In this work, we have developed a promising multiepitope vaccine using TryR.. Multiple epitopes from TryR were identified using different bioinformatics tools to stimulate both humoral and cellular immune responses.

Immunopeptidomics:

Article Title: NOUS-209 off-the-shelf immunotherapy has the potential to hit primary and metachronous colorectal and urothelial cancer in Lynch syndrome
Article Snippet: .. MHC class I peptide binding affinity predictions were 225 conducted using the Immune Epitope Database and Analysis Resource (IEDB) MHC-I prediction tools 226 (RRID:SCR_006604). ..

Article Title: Differential epitope prediction across diverse circulating variants of SARS-COV-2 in Brazil.
Article Snippet: COVID-19, caused by the SARS-COV-2 virus, induces numerous immunological reactions linked to the severity of the clinical condition of those infected.. The surface Spike protein (S protein) present in Sars-CoV-2 is responsible for the infection of host cells.. This protein presents a high rate of mutations, which can increase virus transmissibility, infectivity, and immune evasion.

Article Title: Immuno-Informatics for the Rational Design of Multi-Epitope Vaccine Against Leishmania donovani.
Article Snippet: Trypanothione reductase (TryR) is a unique and key redox protein of Leishmania donovani, the causative agent of visceral Leishmaniasis.. In this work, we have developed a promising multiepitope vaccine using TryR.. Multiple epitopes from TryR were identified using different bioinformatics tools to stimulate both humoral and cellular immune responses.

Binding Assay:

Article Title: NOUS-209 off-the-shelf immunotherapy has the potential to hit primary and metachronous colorectal and urothelial cancer in Lynch syndrome
Article Snippet: .. MHC class I peptide binding affinity predictions were 225 conducted using the Immune Epitope Database and Analysis Resource (IEDB) MHC-I prediction tools 226 (RRID:SCR_006604). ..



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NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
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NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
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NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
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NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
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NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
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NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
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NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of <t>MHC-I–predicted</t> binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.
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Image Search Results


NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of MHC-I–predicted binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.

Journal: Molecular Cancer Therapeutics

Article Title: NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndrome

doi: 10.1158/1535-7163.MCT-25-0864

Figure Lengend Snippet: NOUS-209 FSMs lost, gained, and kept between paired tumors. A, Timeline plot illustrating the follow-up of patients. Filled dots indicate primary and metachronous colorectal cancer and urothelial cancer. Empty circles denote colorectal cancer for which a tumor sample is not available. Light blue lines indicate the time interval between two tumor occurrences. B, Box plot showing, for each patient, the number of NOUS-209 FSMs lost between the first and second tumor, those kept across both tumors, and those gained in the second tumor. C, Box plot showing, for each patient, the median length of NOUS-209 FSMs lost, kept, and gained. D, Bar plot showing for each patient the number of MHC-I–predicted binders (IC 50 < 500 nmol/L) for lost, kept, and gained FSMs, with annotations for B2M IHC results below for primary (P) and metachronous (M) samples. E, Box plots showing, for each patient, the number of predicted epitopes of NOUS-209 FSM lost, kept, and gained. F, Heatmap showing the FSMs lost for each patient, for whom immune editing is hypothesized. FSMs present in the patient's sample are colored if lost or kept. G, Venn diagram showing the overlap of mutations across the three tumors from patient Pt8. H–J, Line plots for patient Pt8 showing the number of NOUS-209 FSM ( H ), their median length ( I ), and the number of predicted good binders ( J ) across the lost, kept, and gained categories. CRC, colorectal cancer; UC, urothelial cancer.

Article Snippet: MHC class I peptide binding affinity predictions were conducted using the Immune Epitope Database and Analysis Resource MHC class I (MHC-I) prediction tools (RRID: SCR_006604).

Techniques: